Real-World Experience Measurement of Liver Iron Concentration by R2 vs. R2 Star MRI in Hemoglobinopathies
نویسندگان
چکیده
منابع مشابه
Multicenter Validation of Spin-Density Projection-Assisted R2-MRI for the Noninvasive Measurement of Liver Iron Concentration
PURPOSE Magnetic resonance imaging (MRI)-based techniques for assessing liver iron concentration (LIC) have been limited by single scanner calibration against biopsy. Here, the calibration of spin-density projection-assisted (SDPA) R2-MRI (FerriScan®) in iron-overloaded β-thalassemia patients treated with the iron chelator, deferasirox, for 12 months is validated. METHODS SDPA R2-MRI measurem...
متن کاملMRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients.
Measurements of hepatic iron concentration (HIC) are important predictors of transfusional iron burden and long-term outcome in patients with transfusion-dependent anemias. The goal of this work was to develop a readily available, noninvasive method for clinical HIC measurement. The relaxation rates R2 (1/T2) and R2* (1/T2*) measured by magnetic resonance imaging (MRI) have different advantages...
متن کاملMeasurement of Liver Iron Concentration by MRI Is Reproducible
PURPOSE The objectives were (i) construction of a phantom to reproduce the behavior of iron overload in the liver by MRI and (ii) assessment of the variability of a previously validated method to quantify liver iron concentration between different MRI devices using the phantom and patients. MATERIALS AND METHODS A phantom reproducing the liver/muscle ratios of two patients with intermediate a...
متن کاملA Comparison Study of Liver R2* Measurement in Pediatric Patients with Iron Overload
INTRODUCTION Iron overload is a common occurrence in children with thalassaemia major and sickle cell disease (due to frequent blood transfusions) or hereditary hemochromatosis. In this patient group, a non-invasive means to quantify iron is extremely attractive compared to conventional liver biopsy for determining total body iron. Recent advances in MRI have enabled non-invasive iron quantific...
متن کاملImproved R2* liver iron concentration assessment using a novel fuzzy c-mean clustering scheme
BACKGROUND In thalassemia patients, R2* liver iron concentration (LIC) measurement is a common clinical tool for assessing iron overload and for determining necessary chelator dose and evaluating its efficacy. Despite the importance of accurate LIC measurement, existing methods suffer from LIC variability, especially at the severe iron overload range due to inclusion of vessel parts in LIC calc...
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ژورنال
عنوان ژورنال: Diagnostics
سال: 2020
ISSN: 2075-4418
DOI: 10.3390/diagnostics10100768